Regenerative Medicine

Regenerative medicine in Duncansville focuses on understanding how we can enhance the body’s natural functions by introducing tissues rich in regenerative cells.

Despite abundant resources on regenerative medicine and cell therapy available through media, online platforms, and pamphlets nationwide, a certain level of ambiguity remains. This generally stems from its status as an advanced treatment option that has only gained broad recognition in recent times.

This piece aims to provide a comprehensive overview of regenerative medicine in Duncansville, assisting you in assessing its potential to fulfill your wellness objectives.

What is Regenerative Medicine?

In Duncansville, regenerative medicine primarily focuses on the methods through which we can enhance the body’s peak performance by implanting tissues abundant in regenerative cells. Subsequently, the restorative impact of regenerative medicine and cell therapy revitalizes your cells, tissues, and organs.

Bone Marrow

Marrow cells are nestled within the depths of our bone cavities, a highly safeguarded region where they exist in abundance, dispersed throughout our skeletal structure. We can harness marrow through a straightforward aspiration or as a refined concentrate, providing millions of these therapeutically advantageous autologous cells.

What are the possible risks involved?

Utilizing bone marrow for therapeutic purposes carries minimal risks. Adhering to sterile procedures and correct protocols ensures the safety of a bone marrow injection.

How long does the process/procedure take?

Day of treatment takes about 1 hour.

What is the long-term outcome?

Post a bone marrow injection, additional injections may or may not be necessary for the patient. The ultimate aim is to permanently resolve the illness or injury, eliminating the need for further interventions. A bone marrow injection introduces a substantial quantity of hematopoietic stem cells to the affected region. The body’s inherent healing process then activates, utilizing these transplanted cells to reconstruct the area. This regeneration phase can last for a period of up to 12 weeks, during which the patient will undergo remodeling.

Adipose

Adipose tissue is employed in regenerative medicine techniques due to the ability to extract mesenchymal regenerative cells from nearly all human body tissues. The key unifying factor for this capability is the vascularization of these tissues, with mesenchymal cells present in non-luminal positions along every blood vessel. These cells adjacent to blood vessels are collectively termed Pericytes. Therapeutically, Adipose-Derived MSCs are utilized for their innate capacity to migrate to inflamed or injured tissue areas, and for their prolific secretion of bioactive substances that possess immunomodulatory and growth-promoting properties.

There are an estimated 150,000 human clinical uses and therapies in MSK applications. All with a remarkable efficacy and safety profile.

Michael J, Moster R, Lukac L et al. Autologous adipose tissue-derived stromal vascular fraction cells application in patients with osteoarthritis. Cell Tranplant. 2015.

1,114 patients followed (1,856 joints injected); Knee (61%), Hip (33.7%) ‘ K-L II (20%), III (69.9%), IV (10.1%)
Age 19-94 (mean 62 yr) Normal BMI (15%), BMI 25-29.9 (56%), BMI >30 (28.3%)
45.2% were candidates for total joint arthroplasty

At 1 year: ‘ 75% score improvement in 59.3% of patients
50% score improvement in 89.1% of patients
0.9% were non-responders
4 required joint replacement
No serious adverse events reported

Why is Adipose used?

Adipose tissue is acknowledged as the body’s largest microvascular organ. Numerous studies indicate that adipose-derived (AD) regenerative/stromal cells of mesodermal lineage yield quantities ranging from 1000 to 2500 times those present in bone marrow. Owing to the straightforward harvesting of adipose tissue, minimal invasive procedures, diverse cellular populations, and significant immune-privileged characteristics, subcutaneous fat reserves are considered a prime source for acquiring regenerative/stromal cells.

What is the long-term outcome?

It is estimated that there are around 150,000 human clinical applications and treatments in the field of musculoskeletal (MSK) medicine, all characterized by an impressive record of effectiveness and safety.

A2M/Fibrinogen

Alpha-2-macroglobulin (A2M) exists in our plasma and serves as a potent suppressor of elements that cause cartilage degradation, effectively decelerating the deterioration of cartilage and inhibiting its loss.

What are the possible risks involved?

A2M, being autologous and derived from your own blood, presents minimal risk when administered by a skilled practitioner. The autologous nature of the cells eliminates the possibility of allergic or immune responses. Adverse reactions or complications associated with A2M are exceedingly uncommon. For further details, it’s advisable to speak with your healthcare provider.

How long does the process/procedure take?

The complete process is likely to last about 1 hour. Throughout this period, your blood will be extracted, treated, and subsequently reinfused into the area affected by injury or illness.

What is the long-term outcome?

Patients may anticipate a notable alleviation in symptoms throughout the recovery period. This approach could negate the necessity for more intrusive interventions like surgery or extended medication regimens. Whereas treatments like corticosteroid injections offer ephemeral respite and halt inflammation, A2M injections promote the injury’s recuperation in a brief span with fewer adverse effects. Improvements in symptoms and functionality are reported by patients, yet patience is required; a timeframe of four to six weeks is typical. Often, two to three sessions are needed before the damaged tissues fully mend, potentially leading to a significant restoration of function and comfort.

Though abundant information on regenerative medicine and cell therapy is accessible through various channels like media, online platforms, and nationwide brochures, a certain ambiguity about these treatments still exists. This primarily stems from their emergence as innovative therapies that have only gained broad accessibility in recent times.

This piece aims to provide a detailed insight into regenerative medicine in Duncansville and assist you in evaluating its potential to meet your health objectives.